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Exploratory assessment of left ventricular strain-volume loops in severe aortic valve diseases
- Source :
- The Journal of Physiology. 595:3961-3971
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Objectives The purpose of this study was to examine left ventricular (LV) strain (ԑ)-volume loops to provide novel insight into the haemodynamic cardiac consequences of aortic valve stenosis (AS) and aortic valve regurgitation (AR). Methods 27 participants were retrospectively recruited: AR (n = 7), AS (n = 10) and controls (n = 10). Standard transthoracic echocardiography was utilised to obtain apical 4 chamber images to construct ԑ-volume relationships were assessed by: Early systolic ԑ (ԑ_ES), slope of ԑ-volume relation during systole (Sslope), End-systolic peak ԑ (peak ԑ), Diastolic uncoupling (systolic ԑ-diastolic ԑ at same volume) during early diastole (UNCOUP_ED) and late diastole (UNCOUP_LD). ROC-curves were used to determine the ability to detect impaired LV function. Results Whilst LV ejection fraction was comparable between groups, longitudinal peak ԑ was similarly reduced compared to controls. In contrast, ԑ_ES and Sslope were lower in both pathologies compared to controls (P 0.05) to distinguish AS vs Controls, AR vs Controls and AS vs AR, respectively. Conclusions Temporal changes in ԑ-volume characteristics provide novel insight into the haemodynamic cardiac impact of AS and AR. Contrary to traditional measures (i.e. ejection fraction, peak ԑ), these novel measures successfully distinguish between the haemodynamic cardiac impact of AS and AR. This article is protected by copyright. All rights reserved.
- Subjects :
- Aortic valve disease
medicine.medical_specialty
Ejection fraction
Physiology
business.industry
Diastole
Hemodynamics
030204 cardiovascular system & hematology
medicine.disease
03 medical and health sciences
0302 clinical medicine
Aortic valve stenosis
Internal medicine
Cardiology
Medicine
030212 general & internal medicine
Systole
business
Aortic valve regurgitation
Left ventricular strain
Subjects
Details
- ISSN :
- 00223751
- Volume :
- 595
- Database :
- OpenAIRE
- Journal :
- The Journal of Physiology
- Accession number :
- edsair.doi...........759c9501a6c8a224fd12b3c2bb96ddbd
- Full Text :
- https://doi.org/10.1113/jp273526