Back to Search
Start Over
A New Trend in the Management of Pediatric Deep Neck Abscess: Achievement of the Medical Treatment Alone
- Source :
- Turk Otolarengoloji Arsivi/Turkish Archives of Otolaryngology.
- Publication Year :
- 2017
- Publisher :
- Galenos Yayinevi, 2017.
-
Abstract
- Objective We aimed to examine the effect of topical dexamethasone by otomicroscopic and histologic examinations for preventing myringosclerosis induced by myringotomy in rat tympanic membranes. Methods Twenty-one Sprague Dawley rats (42 ears) were randomly divided into the following three groups after otomicroscopic examinations: experimental surgical group (5 rats), control group (8 rats), and study group (8 rats). The rats of all the groups underwent myringotomy in both tympanic membranes. Other than myringotomy, no additional procedure was performed for the rats in the experimental surgical group. In the control group, 0.9% NaCl was applied to the ears, whereas in the study groups, topical dexamethasone was applied to the ears. These applications in the control and study groups were repeated for nine days. On the 10th day of the study, the rat ears of all groups underwent otomicroscopic and histologic examinations. The prevalence and process of myringosclerosis were evaluated by otomicroscopic examination, whereas inflammation, membrane thickness, and myringosclerosis intensity were evaluated by histologic examination. Results The growth of myringosclerosis with otomicroscopic examination was lesser in the study group in which topical dexamethasone was applied than the control and the experimental surgical groups. Moreover, it was observed that myringosclerosis effected fewer quadrants in the study group.Histologic examinations revealed that inflammation was significantly lesser in the study group than in the experimental surgical and control groups. The average membrane thickness values were significantly lesser in the study group than in the experimental surgical group. With respect to myringosclerosis growth, no statistically significant difference was observed among all groups, whereas with respect to myringosclerosis intensity, the rat ears in the study group were less severely affected. Conclusion Thus, our study results suggest that applying topical dexamethasone after myringotomy has positive effects on limiting the intensity and prevalence of myringosclerosis.
- Subjects :
- Myringosclerosis
010504 meteorology & atmospheric sciences
business.industry
Topical dexamethasone
medicine.medical_treatment
Significant difference
01 natural sciences
Myringotomy
Tympanic Membranes
Additional procedure
Anesthesia
Sprague dawley rats
Medicine
business
Dexamethasone
0105 earth and related environmental sciences
medicine.drug
Subjects
Details
- ISSN :
- 2149553X and 03044793
- Database :
- OpenAIRE
- Journal :
- Turk Otolarengoloji Arsivi/Turkish Archives of Otolaryngology
- Accession number :
- edsair.doi...........75e23f29ab9995d2b10882d377fa3e47
- Full Text :
- https://doi.org/10.5152/tao.2017.2077