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EUTROC PiSARRO: A phase Ib study combining APR-246 with standard chemotherapy in platinum sensitive relapsed high grade serous ovarian carcinoma (HGSOC)

Authors :
Mikael von Euler
John Green
Ulf Björklund
Hani Gabra
Charlie Gourley
James D. Brenton
Bristi Basu
Austin M. Smith
Ignace Vergote
Source :
Journal of Clinical Oncology. 33:TPS5605-TPS5605
Publication Year :
2015
Publisher :
American Society of Clinical Oncology (ASCO), 2015.

Abstract

TPS5605 Background: p53 mutations are associated with increased chemoresistance. APR-246 is a small molecule that restores mutant p53 to wild type conformation and function (Lambert et al., Cancer ...

Details

ISSN :
15277755 and 0732183X
Volume :
33
Database :
OpenAIRE
Journal :
Journal of Clinical Oncology
Accession number :
edsair.doi...........76429a0ab7c45947fe9fc4c6cf07bfce