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A highly specific and sensitive ratiometric fluorescent probe for carbon monoxide and its bioimaging applications
- Source :
- New Journal of Chemistry. 42:14417-14423
- Publication Year :
- 2018
- Publisher :
- Royal Society of Chemistry (RSC), 2018.
-
Abstract
- The sensitive and accurate detection of intracellular gasotransmitter carbon monoxide (CO) is of great significance for unraveling its diverse cellular functions. Herein, we report a simple highly specific and sensitive 4-hydroxynaphthalimide-based ratiometric fluorescent probe Ratio-CO for monitoring CO levels in living cells. Probe Ratio-CO could quantitatively detect CO in the range of 0–50 μM by the ratiometric fluorescence spectroscopy method and the detection limit was measured to be about 17.9 nM. Additionally, probe Ratio-CO has been proven to possess preeminent selectivity towards CO over other bioactive species. Most importantly, the excellent response properties of probe Ratio-CO enable its applications in the monitoring of the fluctuations of CO levels in living cells by the ratiometric fluorescence imaging technique, and we thus anticipate that this probe would be a novel tool for further elucidating the biological functions of CO in living systems.
- Subjects :
- Detection limit
010405 organic chemistry
Cellular functions
General Chemistry
010402 general chemistry
01 natural sciences
Fluorescence
Catalysis
Ratiometric fluorescence
0104 chemical sciences
chemistry.chemical_compound
chemistry
Materials Chemistry
Biophysics
Imaging technique
Carbon monoxide
Subjects
Details
- ISSN :
- 13699261 and 11440546
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- New Journal of Chemistry
- Accession number :
- edsair.doi...........76759badd33699a79e64902c43d9dbb2