'Greening' of Amizone synthesis when manufacturing

The principles of “green chemistry” have been introduced into the procedure of manufacturing synthesis of Amizone. All starting raw materials as solvents have been assessed in accordance with their human toxicity, danger in production, as well as the possible impact on the environment and cost. According to the results of the analysis isonicotinic acid has been chosen as a starting substance for the synthesis at the first step, and the synthetic procedure without solvents has been proposed. The replacement of acetone with isopropanol has been proposed for the alkylation step according to the data concerning toxicity and manufacturing safety. Aqueous ethanol has been chosen as a solvent for recrystallisation. To reduce the impact on the environment the process of conversion of the benzylamine excess into less toxic and flammable hydrochloride has been recommended.