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Sodium fluoride induces hypertension and cardiac complications through generation of reactive oxygen species and activation of nuclear factor kappa beta

Authors :
Temitope Moses Ige
Adeolu Alex Adedapo
Momoh A. Yakubu
Temitayo Olabisi Ajibade
Ebunoluwa Racheal Asenuga
Temidayo Olutayo Omobowale
Blessing Seun Ogunpolu
Ademola Adetokunbo Oyagbemi
Abiola Olumuyiwa Adejumobi
Source :
Environmental Toxicology. 32:1089-1101
Publication Year :
2016
Publisher :
Wiley, 2016.

Abstract

Human exposure to sodium fluoride through its daily usage is almost inevitable. Cardiovascular and renal dysfunction has been associated with fluoride toxicity. Therefore, this study investigated the mechanism of action of sodium fluoride (NaF) induced hypertension and cardiovascular complications Forty male albino rats of an average of 10 rats per group were used. Group A received clean tap water. Toxicity was induced in Group B to D by administering graded doses of NaF through drinking water ad libitum for 10 days at 150 ppm, 300 ppm, and 600 ppm concentration respectively. Following administration of NaF, there was significant increase in systolic pressure, diastolic pressure and mean arterial pressure. Markers of oxidative stress; malondialdehyde, hydrogen peroxide, advance oxidation protein products, and protein carbonyl were significantly increased in dose-dependent pattern in the cardiac and renal tissues of rats together with significant decrease in the GST activity in NaF-treated rats compared to the control. Also serum markers of inflammation, cardiac, and renal damage including myeloperoxidase, xanthine oxidase, blood urea nitrogen, creatinine, Lactate dehydrogenase (LDH), and Creatinine kinase myocardial band (CK-MB) significantly increased indicating induction of oxidative stress, renal, and cardiac damage after exposure. Histopathology of the kidney and heart revealed aberrations in the histological architecture in NaF-treated rats. Also, immunohistochemistry showed higher expression of nuclear factor kappa beta (NF-kB) in the cardiac and renal tissues of rats administered NaF. Combining all, these results indicate NaF-induced hypertension through generation of reactive oxygen species and activation of renal and cardiac NF-kB expressions. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1089-1101, 2017.

Details

ISSN :
15204081
Volume :
32
Database :
OpenAIRE
Journal :
Environmental Toxicology
Accession number :
edsair.doi...........779b89a2925ac4c1b336d9f66cbaa37a
Full Text :
https://doi.org/10.1002/tox.22306