ChemInform Abstract: Novel Synthesis of Tryptamine Derived 4-Hydroxy-4-arylthiazolidine-2-thiones and 4-Arylthiazole-2(3H)-thiones by Multicomponent Reactions

An efficient one-pot multicomponent synthesis of 3-(2-(1H-indol-3-yl)ethyl)-4-hydroxy-4-arylthiazolidine-2-thione and 3-(2-(1H-indol-3-yl)ethyl)-4-arylthiazole-2(3H)-thione has been developed from a multicomponent reaction of tryptamine, carbon disulfide and phenacyl bromide. This protocol has an advantage such as operational simplicity, short reaction time, and affording good to excellent yields.