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Understanding centrality-lethality rule in yeast Protein-Protein Interaction network by topological property
- Source :
- 2011 6th IEEE Joint International Information Technology and Artificial Intelligence Conference.
- Publication Year :
- 2011
- Publisher :
- IEEE, 2011.
-
Abstract
- One of the most important problems in biology is to discover the relationship between topological properties and functional features of proteins in Protein-Protein Interaction (PPI) network. The centrality-lethality rule reveals that hub proteins tend to be more essential than non-hub proteins. Why hub proteins tend to be more essential? Here, we classified hub proteins into two types: essential hub and nonessential hub. We found that essential hubs are more important to the survival of the cell and they can be called intra-modular hubs while nonessential hubs tend to be inter-modular hubs.
- Subjects :
- Physics::Physics and Society
Topological property
Quantitative Biology::Biomolecules
Computer science
Quantitative Biology::Molecular Networks
Functional features
Computer Science::Social and Information Networks
Computational biology
Bioinformatics
Yeast
Protein protein interaction network
Quantitative Biology::Subcellular Processes
Centrality
Cellular biophysics
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- 2011 6th IEEE Joint International Information Technology and Artificial Intelligence Conference
- Accession number :
- edsair.doi...........781c2af275a2bf0db73e5d550ce8e723