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Synthesis of a new chiral amino phosphine ligand and its application in the asymmetric allylic alkylation (AAA) reaction
- Source :
- Tetrahedron: Asymmetry. 18:1043-1047
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- This article describes the synthesis of a new chiral amino phosphine ligand based on an amino naphthol starting material, which is resolved efficiently by using l -tartaric acid. The asymmetric induction of the ligand in the Pd(0)-catalyzed allylic substitution of 1,3-diphenylprop-2-en-1-yl acetate with dimethyl malonate was investigated. Good yields and enantiomeric excesses up to 78% of the product were obtained.
Details
- ISSN :
- 09574166
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Tetrahedron: Asymmetry
- Accession number :
- edsair.doi...........78e2263d2782e01021e25f950a4cbb01