Formal oxygen atom insertion as a skeletal editing step: rapid access natural product-inspired bispiro[oxindole-oxazinane] hybrids

Strategies to single-step edit the core skeleton of structurally complex compounds still remain highly desirable but challenging. Herein an unexpected discovery to access natural product dehydrocostus lactone/parthenolide-inspired bispiro[oxindole-oxazinane] hybrids enabled...