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Experimental and simulation studies of strontium/zinc-codoped hydroxyapatite porous scaffolds with excellent osteoinductivity and antibacterial activity
- Source :
- Applied Surface Science. 462:118-126
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- The porous scaffold of hydroxyapatite (HA) is highly promising for application in clinics owing to its interconnected porous structure, excellent mechanical properties, biocompatibility, and biological activity; however, the effectiveness of its antibacterial properties and osteoinductivity limits its wide usage. In the present study, strontium (Sr), zinc (Zn), and Sr/Zn-codoped porous scaffolds of HA were prepared by an ion-exchange method and a foaming method. The results based on the density functional theory (DFT) and experimental methods suggested that Sr and Zn were successfully doped into the HA lattice structure, thereby changing the lattice parameters of HA. Sr-doped, Zn-doped, and codoped porous HA scaffolds promoted the proliferation of bone marrow stromal cells (BMSCs), and Sr-doped and codoped porous HA scaffolds promoted BMSC differentiation. In addition, Zn-doped and codoped porous HA scaffolds exhibited excellent antibacterial properties. In short, the codoped HA porous scaffolds, prepared using the simple, facile, and mild ion-exchange, and foaming methods, had good biocompatibility, osteoinductivity, and antibacterial properties, which could effectively inhibit microbial infection and promote bone tissue regeneration in the process of bone repair. Moreover, they are hopeful to be good bone replacement material in clinical application.
- Subjects :
- Materials science
Biocompatibility
General Physics and Astronomy
chemistry.chemical_element
02 engineering and technology
Zinc
Bone healing
010402 general chemistry
Bone tissue
01 natural sciences
medicine
Porosity
Strontium
technology, industry, and agriculture
Surfaces and Interfaces
General Chemistry
021001 nanoscience & nanotechnology
Condensed Matter Physics
Porous scaffold
0104 chemical sciences
Surfaces, Coatings and Films
medicine.anatomical_structure
chemistry
Chemical engineering
0210 nano-technology
Antibacterial activity
Subjects
Details
- ISSN :
- 01694332
- Volume :
- 462
- Database :
- OpenAIRE
- Journal :
- Applied Surface Science
- Accession number :
- edsair.doi...........7a19e7933c55ff369865be0828dfc03e