Prediction Rule Generation of MHC Class I Binding Peptides Using ANN and GA

A new method is proposed for generating if-then rules to predict peptide binding to class I MHC proteins, from the amino acid sequence of any protein with known binders and non-binders. In this paper, we present an approach based on artificial neural networks (ANN) and knowledge-based genetic algorithm (KBGA) to predict the binding of peptides to MHC class I molecules. Our method includes rule extraction from a trained neural network and then enhancing the extracted rules by genetic evolution. Experimental results show that the method could generate new rules for MHC class I binding peptides prediction.