Back to Search
Start Over
Expression of β-catenin and C-myc in thymoma and the association with biological features
- Source :
- Chinese Journal of Cancer Research. 18:142-148
- Publication Year :
- 2006
- Publisher :
- Chinese Journal of Cancer Research, 2006.
-
Abstract
- β-catenin is closely associated with proliferation, differentiation, invasion and metastasis of tumor cells. C-myc is proved to be abnormally expressed in various kinds of malignant neoplasmas. This study is aimed to investigate the features of β-catenin and C-myc expressions in thymoma and the corresponding clinical significance. Immunochemistry was used to detect the features of expressions of β-catenin and C-myc in thymoma and normal thymus. Of the 105 samples, according to Beratz classification, there were: epithelial type 34; lymphocyte type 35; mixed type 31 and shuttle cell type 5. According to Masaoka classification, there were: stage 1: 38; stage 2: 32; stage 3: 20 and stage 4: 15. According to WHO classification, there were: type A 20; type AB 19; type B1 21; type B2 17; type B3 13 and type C 15. Different ways of expression was revealed in different stages of thymomas. With the progress of thymoma, the expression of β-catenin on cell membrane decreased, while increased in cytoplasma and nucleus, even with nucleus shift. The expression of C-myc increased in invasive thymoma. Abnormal expression of β-catenin and C-myc increased, with significant difference(P
Details
- ISSN :
- 19930631 and 10009604
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Chinese Journal of Cancer Research
- Accession number :
- edsair.doi...........7abce90446215c21a65d799dba6edf06