Extractive Spectrophotometric Determination of Nicergoline Through Ion-pair Complexation Reaction

Two simple, sensitive, selective, accurate and economical spectrophotometric methods (A and B) have been described in the present work for the determination of Nicergoline in bulk drug and pharmaceutical formulations (tablets). Methods - A/B are based on the formation of orange red / yellow colored ion-association complexes between Nicergoline and Tropaeolin ooo (TPooo) / Alizarine Red S (ARS) in acid medium followed by their extraction with chloroform, exhibiting absorption maxima at 490nm / 430nm, and obeying Beer's law in the concentration range of 2.5- 12.5µg/ml. Statistical analysis of the results of the proposed methods reveals high accuracy and good precision. The proposed methods could be successfully extended to the commercial pharmaceutical formulations containing Nicergoline.