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A facile synthesis of 3-trifluoromethyl-1,2,4-oxadiazoles from cyanamides
- Source :
- Tetrahedron Letters. 55:4433-4436
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- A safe and facile method for the formation of 3-trifluoromethyl-5-amino-1,2,4-oxadiazoles, via a reversed addition of hydroxylamine to cyanamides, is reported. This two-pot procedure is suitable to scale-up and avoids the hazards associated with trifluoromethyl amidoxime synthesis.
Details
- ISSN :
- 00404039
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Tetrahedron Letters
- Accession number :
- edsair.doi...........7b7c0683b0c0ec619176d31bd25c2c5a
- Full Text :
- https://doi.org/10.1016/j.tetlet.2014.06.019