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Cerebellar repetitive transcranial magnetic stimulation for patients with essential tremor
- Source :
- Parkinsonism & Related Disorders. 64:304-307
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Introduction The possibility of repetitive transcranial magnetic stimulation (rTMS) as an alternative therapy for essential tremor (ET) patients has emerged. However, its effect on medicated ET patients is lacking. The aim of this pilot study was to investigate the effect of cerebellar low-frequency rTMS as an “add-on” treatment. Methods In this single-blinded, randomized, sham-controlled pilot study, patients with ET were randomized into two groups, one receiving real-rTMS and the other sham-rTMS. For 5 days, 1200 stimulations per day were applied to the bilateral cerebellar hemispheres at an intensity of 90% of the resting motor threshold (RMT) with a frequency of 1-Hz. Motor evoked potentials (MEPs) and the Fahn-Tolosa-Marin tremor rating scales (TRS) were measured before, immediately, and 4 weeks after the completion of the rTMS procedures. All patients continued taking medications during all procedures. Results Among 22 patients, 12 and 10 patients were randomized into the real- and sham-rTMS groups, respectively. Repeated analysis of variance (ANOVA) measurements showed that the total TRS, TRS-A and B were changed both in real and sham-rTMS groups without interaction between time and group. TRS-C and MEPs, were not significantly changed at each follow-up point in either the real or sham-rTMS sessions. Conclusion We conclude that cerebellar low-frequency rTMS is safe, but has no significant effect as an “add-on” therapy in patients with ET.
- Subjects :
- 0301 basic medicine
Motor threshold
Cerebellum
Essential tremor
Alternative therapy
business.industry
medicine.medical_treatment
medicine.disease
behavioral disciplines and activities
Transcranial magnetic stimulation
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
medicine.anatomical_structure
nervous system
Neurology
Rating scale
Anesthesia
medicine
In patient
Neurology (clinical)
Analysis of variance
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 13538020
- Volume :
- 64
- Database :
- OpenAIRE
- Journal :
- Parkinsonism & Related Disorders
- Accession number :
- edsair.doi...........7ba92d6eb8303bb25683859c2fb557ff
- Full Text :
- https://doi.org/10.1016/j.parkreldis.2019.03.019