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A rationally engineered specific near-infrared fluorogenic substrate of human pancreatic lipase for functional imaging and inhibitor screening

Authors :
Fan-Bin Hou
Na Zhang
Xu-Dong Hou
Wei Liu
Yu-Fan Fan
Guang-Hao Zhu
Yue Wu
Meng-Ru Sun
Bei Zhao
Guang-Bo Ge
Ping Wang
Source :
The Analyst. 148:2225-2236
Publication Year :
2023
Publisher :
Royal Society of Chemistry (RSC), 2023.

Abstract

A novel NIR fluorogenic substrate was rationally designed towards hPL, which can detect endogenous PL in living cells and tissues, and enable visual high-throughput screening of hPL inhibitors.

Details

ISSN :
13645528 and 00032654
Volume :
148
Database :
OpenAIRE
Journal :
The Analyst
Accession number :
edsair.doi...........7c279b50c60a9a3425b254efa8955789
Full Text :
https://doi.org/10.1039/d3an00198a