Back to Search
Start Over
Office-based biopsies for laryngeal lesions: Analysis of consecutive 581 cases
- Source :
- The Laryngoscope. 126:2513-2519
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Objectives/Hypothesis Office-based biopsy (OBB) is widely used to diagnose suspicious laryngeal lesions. However, its routine use is still controversial and the algorithm for clinical strategy is not concrete. We tried to evaluate the accuracy of OBB as a diagnostic tool for laryngeal malignancy. Methods Medical data of 581 patients undergoing OBB were reviewed. Diagnostic values of OBB were analyzed for malignancy and malignancy/premalignancy. False negative rates (FNRs) were analyzed according to subsites, lesion sizes, and morphology. Results The collection rate of adequate specimens was 99.1%, and there were no complications during OBB. The false omission rates for malignancy of benign lesion; mild, moderate, and severe dysplasia; and carcinoma in situ (CIS) were 5.1%, 11.9%, 14.3%, 50.0%, and 100.0%, respectively. Sensitivity, specificity, positive predictive value, and negative predictive value for malignancy in OBB were 78.2%, 100.0%, 100.0%, and 87.3%, respectively. Those for malignancy/premalignancy in OBB were 88.2%, 86.7%, 85.7%, and 89.1%, respectively. The high FNRs were reported in glottis lesions (27.0%) and small lesions below 1 cm (27.5%). Morphologically fungating lesions showed low FNR (9.1%) compared to nonfungating ones. Conclusion Office-based biopsy could be used as an initial diagnostic tool for laryngeal malignancy for early detection and avoidance of general anesthesia. However, operative re-biopsy should be considered when severe dysplasia or CIS were reported in OBB, or when the lesions are clinically suspicious for malignancy. Level of Evidence 4. Laryngoscope, 2016
- Subjects :
- Larynx
Office based
medicine.medical_specialty
Glottis
Suspicious for Malignancy
medicine.diagnostic_test
business.industry
Carcinoma in situ
Malignancy
medicine.disease
Lesion
03 medical and health sciences
0302 clinical medicine
medicine.anatomical_structure
Otorhinolaryngology
030220 oncology & carcinogenesis
Biopsy
medicine
Radiology
medicine.symptom
030223 otorhinolaryngology
business
Subjects
Details
- ISSN :
- 0023852X
- Volume :
- 126
- Database :
- OpenAIRE
- Journal :
- The Laryngoscope
- Accession number :
- edsair.doi...........7c69958bdd7e4d5557f4ee17813e83db