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Comparison of Endothelial Dysfunction in Coronary Arteries with Bare Metal and 2nd-Generation Drug-Eluting Stents
- Source :
- Journal of Atherosclerosis and Thrombosis. 29:379-392
- Publication Year :
- 2022
- Publisher :
- Japan Atherosclerosis Society, 2022.
-
Abstract
- Aims Previous studies suggested that implantation with a 1st-generation DES was associated with coronary endothelial dysfunction, which was associated with Rho-kinase activation. Second-generation drug-eluting stents (DESs) may preserve coronary endothelial function in stented coronary arteries; however, because of methodological limitations, further study is needed to clarify the association between 2nd-generation DESs and coronary endothelial dysfunction. Methods We retrospectively analysed the CuVIC trial database, where we identified 112 patients who underwent coronary stenting in the left coronary arteries with either a bare metal stent (BMS, n=53) or 2nd-generation DES (n=59). We compared vasomotions of target vessels with stents and non-target vessels without stents. Furthermore, we measured the Rho-kinase activation detected in mononucleocytes from aortic and coronary sinus blood. Results ACh-induced vasoconstrictive responses of target vessels were not enhanced with a 2nd-generation DES (45±21% vs. 44±20%, P=0.56, paired t-test), but significantly enhanced in the coronary arteries with a BMS (50±18% vs. 42±20%, P=0.002). Rho-kinase activation did not differ between patients with a BMS and 2nd-generation DES. In the target vessels with a BMS, large late lumen loss and acute coronary syndrome (ACS) at the index percutaneous coronary intervention (PCI) were associated with ACh-induced enhanced coronary vasoconstrictive responses. Conclusions Evaluation of ACh-induced vasomotion of target vessels comparing with non-target vessels revealed that 2nd-generation DESs were not associated with coronary endothelial dysfunction in target vessels, nor activation of Rho-kinase in the coronary sinus blood 6-8 months after stenting.
- Subjects :
- Bare-metal stent
medicine.medical_specialty
Acute coronary syndrome
business.industry
medicine.medical_treatment
Biochemistry (medical)
Percutaneous coronary intervention
Vasomotion
030204 cardiovascular system & hematology
medicine.disease
Coronary arteries
03 medical and health sciences
0302 clinical medicine
medicine.anatomical_structure
Internal medicine
Conventional PCI
Internal Medicine
medicine
Cardiology
Endothelial dysfunction
Cardiology and Cardiovascular Medicine
business
030217 neurology & neurosurgery
Coronary sinus
Subjects
Details
- ISSN :
- 18803873 and 13403478
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Journal of Atherosclerosis and Thrombosis
- Accession number :
- edsair.doi...........7d2637d52dc9ef9b987aca30096d2fcc