ChemInform Abstract: Synthesis and Antimicrobial Activity of Some New Triazino-, Triazolo-, and Pyrazolopyridazine Derivatives

The reaction of 3-hydrazino-4,5,6-triphenylpyridazine with phenacyl bromide afforded triazolopyridazine, while the reaction with different aldehydes gave the corresponding 3-arylidene hydrazinopyridazine derivatives which, on reaction with Br 2/ Na 2 CO 3 , gave the corresponding triazinopyridazines. Also, fusion with ethyl acetoacetate, ethyl bertzoylacetate, diethyl malonate, or ethyl phenylacetoacetate gave the corresponding pyrazolo- and triazinopyridazine derivatives. The antimicrobial activity of some of the new compounds has been discussed.