Arthropathy in patients with hemophilia in the antananarivo hemophilia treatment center

Hemophilia is a hereditary bleeding disorder related to X chromosome due to a coagulation factor deficiency Sixty six patients with hemophilia PwH A and fifty four patients with hemophilia B are until now registered at the HTC in Madagascar The objective of this study is to describe the epidemioclinical and therapeutic profile of arthritis in Malagasy hemophiliacs at the HTC This is a monocentric retrospective and descriptive study extending over a period of months from September to March including cases of arthropathy The age group between and and patients with hemophilia A severe were the most affected Hemarthrosis has been frequent in to times a year Arthropathy reached the knees in of cases and has been debilitating in almost all of cases Care has been essentially based on clot factor substitution Repetition of hemarthrosis episodes leads to arthropathy which can be avoided by early infusion of concentrate clot factor