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Хронічний шкірно-слизовий кандидоз як первинний імунодефіцит у дітей

Authors :
L.I. Chernyshova
L. Marodi
V.P. Chernyshov
A.P. Volokha
A.V. Bondarenko
F.I. Lapiy
Source :
CHILD`S HEALTH. :112-120
Publication Year :
2013
Publisher :
Publishing House Zaslavsky, 2013.

Abstract

Chronic mucocutaneous candidiasis is a genetically heterogeneous group of disorders associated with mutations in genes STAT1, IL17RA, IL17F, AIRE, STAT3, TYK2, IL12RB1, and IL12B. Chronic mucocutaneous candidiasis can present as a clinical syndrome in primary and secondary immunodeficiency, or distinct nosological entity of primary immunodeficiency. Today the major components of immunopathology of chronic mucocutaneous candidiasis are defects of immune response, mediated by IL-17 and IL-22. The article describes two cases of chronic mucocutaneous candidiasis, associated with mutations in gene STAT1, in children.

Details

ISSN :
23071168 and 22240551
Database :
OpenAIRE
Journal :
CHILD`S HEALTH
Accession number :
edsair.doi...........7e5af6b6e8f4f7189e4fa104722144b2
Full Text :
https://doi.org/10.22141/2224-0551.2.45.2013.88248