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Heteroaryl-O-glucosides as Novel Sodium Glucose Co-Transporter 2 Inhibitors. Part 1

Authors :
Mona Patel
Mary Pat Beavers
Philip J. Rybczynski
Geoffrey G. Cox
Keith T. Demarest
Bruce R. Conway
Maud Urbanski
Haiyan Bian
Xiaoyan Zhang
Roxanne E. Zeck
Source :
ChemInform. 37
Publication Year :
2006
Publisher :
Wiley, 2006.

Abstract

A series of benzo-fused heteroaryl-O-glucosides was synthesized and evaluated in SGLT1 and 2 cell-based functional assays. Indole-O-glucoside 10a and benzimidazole-O-glucoside 18 exhibited potent in vitro SGLT2 inhibitory activity.

Details

ISSN :
15222667 and 09317597
Volume :
37
Database :
OpenAIRE
Journal :
ChemInform
Accession number :
edsair.doi...........7e80dacc51a1ad513a283837d36be4ba
Full Text :
https://doi.org/10.1002/chin.200609205