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The vital role of Gli1 + mesenchymal stem cells in tissue development and homeostasis
- Source :
- Journal of Cellular Physiology. 236:6077-6089
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- The hedgehog (Hh) signaling pathway plays an essential role in both tissue development and homeostasis. Glioma-associated oncogene homolog 1 (Gli1) is one of the vital transcriptional factors as well as the direct target gene in the Hh signaling pathway. The cells expressing the Gli1 gene (Gli1+ cells) have been identified as mesenchymal stem cells (MSCs) that are responsible for various tissue developments, homeostasis, and injury repair. This review outlines some recent discoveries on the crucial roles of Gli1+ MSCs in the development and homeostasis of varieties of hard and soft tissues.
- Subjects :
- 0301 basic medicine
integumentary system
Oncogene
Physiology
Clinical Biochemistry
Mesenchymal stem cell
Cell Biology
Biology
Hedgehog signaling pathway
Cell biology
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
GLI1
030220 oncology & carcinogenesis
biology.protein
Signal transduction
Transcription factor
Hedgehog
Homeostasis
Subjects
Details
- ISSN :
- 10974652 and 00219541
- Volume :
- 236
- Database :
- OpenAIRE
- Journal :
- Journal of Cellular Physiology
- Accession number :
- edsair.doi...........7f563e200f9fe3fa447cfbd18eab8d46