Effectiveness of inhaled colistin by iNeb® device in non-CF bronchiectasis and chronic pseudomonas infection

Introduction: Chronic bronchial Pseudomonas (PA) infection is associated with increased exacerbations and hospitalizations in patients with non-CF bronchiectasis (NCFBC). Aims: To demonstrate that treatment with Colistin by I-neb® reduces exacerbations and hospitalizations, and that this is related with adherence to treatment and ability to use the device. Methods: Observational study comparing exacerbations and hospitalizations in the pre- and post-initiation of treatment with Colistin year, analyzing whether adherence and ability to use the I-neb® influence the results. Results: 19 patients (68.4% male) were collected with a median age of 70(21). 100% of patients had exacerbations in the previous year, median 5(6); compared with 73.7% in the following year, median 1(3), p Conclusions: Treatment with Colistin by I-neb® device reduces exacerbations and hospitalizations in patients with NCFBC and chronic PA infection. This effect on exacerbations is clearly related to adherence. The use of I-neb® is simple and helps proper drug administration in most patients.