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Antifatigue effects of peptide isolated from sheep placenta
- Source :
- Chinese Herbal Medicines. 10:279-284
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Objective Fatigue has become one of the major threats to human health in the 21st century. Traditional Chinese medicine (TCM), which proved to be safer and more effective, has become a hot spot in antifatigue research. Human placenta, also called “Ziheche”, has drawn great attention in the antifatigue effect since the Tang dynasty. However, the shortage of human placenta restricts wide usage of it. According to the theory of TCM, sheep placenta (SP) also has the effect of nourishing blood, tranquilization, nourishing skin, and prolongation of life. The aim of this study was to examine the antifatigue effects of sheep placenta peptide (SPP), an extract of sheep placenta, in mice and the mechanism was also studied. Methods Peptide from fresh SP was extracted via enzymolysis. SPP (0.13 g/kg) and soybean peptide (0.65 g/kg) were administrated orally and daily to mice for four weeks. Antifatigue effects of SPP were estimated on weight-loaded swimming test; A non-weight-loaded swimming test was conducted to elucidate underlying the mechanisms of the anti-fatigue effects. Results Administration of SPP prolonged the weight-loaded swimming time in mice. In addition, SPP significantly decreased the levels of muscle malondialdehyde (MDA) and serum lactic acid (LD), and increased the activities of muscle glutathione peroxidase (GSH), and superoxide dismutase (SOD) and liver glycogen in mice after non-weight-loaded swimming test. Moreover, the electron microscope observation showed that the muscle fiber bundle ranked neatly, the H band, I band, Z line as well as M line were clear and the numbers of mitochondria was normal though some of the mitochondria were swell in SPP treated mice after non-weight-loaded swimming test. Conclusion SPP possesses potent abilities for antifatigue; Increasing the anti-oxidant activities and energy reserve as well as improving the ultrastructures in gastrocnemius muscle cells, which may be the mechanisms of SPP exerting its antifatigue effects.
- Subjects :
- 0301 basic medicine
Pharmacology
chemistry.chemical_classification
Glycogen
Glutathione peroxidase
04 agricultural and veterinary sciences
Glutathione
Biology
Malondialdehyde
040401 food science
Lactic acid
Superoxide dismutase
03 medical and health sciences
chemistry.chemical_compound
Gastrocnemius muscle
030104 developmental biology
0404 agricultural biotechnology
medicine.anatomical_structure
Complementary and alternative medicine
chemistry
Placenta
biology.protein
medicine
Pharmacology (medical)
Subjects
Details
- ISSN :
- 16746384
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Chinese Herbal Medicines
- Accession number :
- edsair.doi...........8026e02daad74622c657c2b4bc67689b