Back to Search
Start Over
HEPATOPROTECTIVE ACTIVITY OF ASPARGUS RACEMOSUS ROOT EXTRACT ON LIPOPOLYSACCHARIDE INDUCED OXIDATIVE STRESS IN RATS
- Source :
- Universal Journal of Pharmaceutical Research.
- Publication Year :
- 2019
- Publisher :
- Society of Pharmaceutical Tecnocrats, 2019.
-
Abstract
- Objective: Lipopolysaccharide (endotoxin) produces an inflammatory condition leading to multiple organ failure. LPS most potent bacterial products are used for induction of host oxidative stress responses and liver injury. Methods: Present study was undertaken to investigate the effect of Asparagus racemosus Willd. root extract in lipopolysaccharide (LPS) induced oxidative stress in rats by measuring oxidative stress markers, nitric oxide, liver function test and cytokines. Results: The obtained data showed that LPS administration significantly reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT), total cholesterol (TC) and albumin (ALB). There was significant increase in malondialdehyde (MDA), cytokines activity, serum aspartate transaminase(AST), alanine transaminase(ALT), alkaline phosphate (ALP), total bilirubin (TB) and nitric oxide(NO). Conclusion: The methanolic extract of Asparagus racemosus (MEAR) administration significantly (P
- Subjects :
- Liver injury
biology
medicine.diagnostic_test
business.industry
Aspartate transaminase
Pharmacology
biology.organism_classification
medicine.disease
Malondialdehyde
medicine.disease_cause
chemistry.chemical_compound
chemistry
Alanine transaminase
medicine
biology.protein
Asparagus racemosus
Liver function
business
Liver function tests
Oxidative stress
Subjects
Details
- ISSN :
- 24568058
- Database :
- OpenAIRE
- Journal :
- Universal Journal of Pharmaceutical Research
- Accession number :
- edsair.doi...........813690630170419478ff95e1ae818ddd