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Weight loss and carotid intima-media thickness-a meta-analysis
- Source :
- Obesity. 25:357-362
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Objective Obesity is a risk factor for clinical cardiovascular disease, putatively via increased burden of atherosclerosis. It remains contentious as to whether weight loss in people with obesity is accompanied by a reduction in intima-media thickness, a noninvasive marker of subclinical atherosclerosis, consistent with a lowering of risk of cardiovascular events. Methods A systematic literature search was performed to identify all surgical and nonsurgical weight loss interventions that reported intima-media thickness. A meta-analysis was undertaken to obtain pooled estimates for change in intima-media thickness. Results From the 3,197 articles screened, 9 studies were included in the meta-analysis, with a total of 393 participants who lost an average of 16 kg (95% CI 9.4–22.5) of body weight over an average follow-up of 20 months. The pooled mean change in carotid intima-media thickness was −0.03 mm (95% CI −0.05 to −0.01), which was similar between surgical and nonsurgical interventions. Conclusions In people with obesity, weight loss was associated with a reduction in carotid intima-media thickness, consistent with a lowering in risk of cardiovascular events.
- Subjects :
- medicine.medical_specialty
Nutrition and Dietetics
business.industry
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
Disease
030204 cardiovascular system & hematology
medicine.disease
Obesity
Surgery
03 medical and health sciences
0302 clinical medicine
Endocrinology
Pooled variance
Intima-media thickness
Weight loss
Internal medicine
Subclinical atherosclerosis
Meta-analysis
medicine
Cardiology
030212 general & internal medicine
medicine.symptom
Risk factor
business
Subjects
Details
- ISSN :
- 19307381
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Obesity
- Accession number :
- edsair.doi...........81ad6d85378f6bbbebfc25e279af6678