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Primary lymphoma of the central nervous system. An unresolved therapeutic problem
- Source :
- Cancer. 65:322-326
- Publication Year :
- 1990
- Publisher :
- Wiley, 1990.
-
Abstract
- From January 1979 to December 1987, 35 cases of primary central nervous system lymphoma (CNS-L) were treated. We recently reviewed these cases focusing on treatment results, treatment modalities, and radiotherapy (RT) or chemotherapy-radiotherapy (CT-RT). Variables such as age, risk factors, presenting symptoms, and histologic condition (all were high-grade or intermediate-grade non-Hodgkin's lymphomas [NHL]) and radiologic data were similar to those of series reported previously. The median survival time was 36 months (+/- 0.2 months) and the disease-free survival (DFS) time was 16 months (+/- 0.12 months). Twelve of 32 patients evaluable for treatment results experienced a recurrence (all but one occurred in the CNS). The DFS rate was 70% for the CT-RT group and 50% for the RT group (median follow-up time, 24 months). Therapeutic results in CNS-L are discussed with special emphasis on a putative role of CT in the management of this rare type of tumor.
- Subjects :
- Cancer Research
medicine.medical_specialty
Chemotherapy
business.industry
medicine.medical_treatment
Central nervous system
Primary central nervous system lymphoma
Treatment results
medicine.disease
Gastroenterology
Surgery
Radiation therapy
medicine.anatomical_structure
Oncology
Internal medicine
Primary lymphoma
medicine
Risk factor
business
Median survival
Subjects
Details
- ISSN :
- 10970142 and 0008543X
- Volume :
- 65
- Database :
- OpenAIRE
- Journal :
- Cancer
- Accession number :
- edsair.doi...........825ab0b7451fa3fa3be29b0c714725d9