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Exposure to methylergonovine maleate as a cause of sirenomelia
- Source :
- Birth Defects Research Part A: Clinical and Molecular Teratology. 106:643-647
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Background Sirenomelia is a rare, but deadly condition characterized by fusion of the lower limbs, lower spinal column defects, severe malformations of the urogenital and lower gastrointestinal tract, and an aberrant abdominal umbilical artery. Methods The two main hypotheses, not mutually exclusive, that have been advanced to explain the pathogenesis of sirenomelia are the blastogenetic theory and the vascular disruption theory. Results We describe a case of sirenomelia, probably associated with the use of methylergonovine maleate, an ergot alkaloid, during the first weeks of pregnancy. Conclusion On the basis of the mechanisms of vascular disruption and early administration of methylergonovine maleate at a critical stage of organogenesis, we conclude that exposure to methylergonovine maleate could be the cause of the development of sirenomelia. Birth Defects Research (Part A) 106:643–647, 2016. © 2016 Wiley Periodicals, Inc.
- Subjects :
- 0301 basic medicine
Embryology
Pregnancy
medicine.medical_specialty
030219 obstetrics & reproductive medicine
Obstetrics
business.industry
Physiology
Umbilical artery
General Medicine
030105 genetics & heredity
medicine.disease
Spinal column
Teratology
Ectromelia
03 medical and health sciences
0302 clinical medicine
Sirenomelia
medicine.artery
Pediatrics, Perinatology and Child Health
medicine
Methylergonovine
business
Developmental Biology
Methylergonovine Maleate
Subjects
Details
- ISSN :
- 15420752
- Volume :
- 106
- Database :
- OpenAIRE
- Journal :
- Birth Defects Research Part A: Clinical and Molecular Teratology
- Accession number :
- edsair.doi...........83193dad7630e36123ff65cc7514571d
- Full Text :
- https://doi.org/10.1002/bdra.23503