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ORIGINAL ARTICLE: Progesterone-Induced Blocking Factor and Cytokine Profile in Women with Threatened Pre-Term Delivery
- Source :
- American Journal of Reproductive Immunology. 61:330-337
- Publication Year :
- 2009
- Publisher :
- Wiley, 2009.
-
Abstract
- Problem The objective of this study was to compare serum concentrations of progesterone-induced blocking factor (PIBF), anti-inflammatory (IL-10), and pro-inflammatory (IL-6, TNFα, and IFNγ) cytokines of women with threatened pre-term delivery, with those of women with normal pregnancy and to evaluate the impact of PIBF on the outcome of pregnancy. Method of study A prospective study was conducted on a sample of 30 women with threatened pre-term delivery (study group) and 20 healthy pregnant women (control group) between the 24th and 37th gestational weeks. Serum PIBF, anti-inflammatory (IL-10), and pro-inflammatory (IL-6, TNFα, and IFNγ) cytokine concentrations were measured by enzyme-linked immunosorbent assay (ELISA). Results Thirteen of 30 patients (43.3%) with symptoms of threatened pre-term delivery, and one of 20 patients (5%) in the control group delivered before the 37th week of gestation. Mean PIBF concentrations in serum samples of patients with threatened pre-term delivery were significantly lower than in those of healthy pregnant women (171.12 ± 162.06 ng/mL versus 272.85 ± 114.87 ng/mL; P
- Subjects :
- Pregnancy
business.industry
medicine.medical_treatment
Immunology
Obstetrics and Gynecology
Physiology
Blocking factor
medicine.disease
Proinflammatory cytokine
Cytokine
Reproductive Medicine
Threatened species
medicine
Immunology and Allergy
Gestation
Tumor necrosis factor alpha
Prospective cohort study
business
Subjects
Details
- ISSN :
- 10467408
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- American Journal of Reproductive Immunology
- Accession number :
- edsair.doi...........8331009551a89d5980e77ca8307785d0