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Anthelminthic Activity of Annona reticulata Seed Extracts

Authors :
H. Joy Hoskeri
A. B. Vedamurthy
D. R. Yashwanth Kumar
Source :
British Journal of Pharmaceutical Research. 4:669-675
Publication Year :
2014
Publisher :
Sciencedomain International, 2014.

Abstract

Aims: To evaluate the anthelminthic activity of Annona reticulata seeds extracts against Pheretima posthuma. Study Design: Helminth infections have tormented humans and animals for thousands of years. The indiscriminate uses of the anthelminthic drugs have lead to the emergence of resistant helminths against many anthelminthic agents. Thus the need for the treatment of helminthic infections and the prevention of the emergence of resistant strains has led to the screening medicinal plants for their anthelminthic activity. Place and Duration of Study: Department of Biotechnology, The Oxford College of Science, Bangalore, Karnataka, India, between January 2012 and March 2012. Methodology: The main aim of the present exploratory study is to evaluate the anthelminthic activity of A. reticulata seeds extracts. The in vitro studies revealed that the anthelminthic effects of crude chloroform and ethanolic extracts of A. reticulata on Pheretima posthuma was evident from induction of paralysis and mortality. Piperazine citrate was used as the standard reference drug and normal saline as a control group. Results: Among all the concentrations of chloroform and ethanolic extracts tested, 12.5 mg/ml showed significant (p

Details

ISSN :
22312919
Volume :
4
Database :
OpenAIRE
Journal :
British Journal of Pharmaceutical Research
Accession number :
edsair.doi...........836dbe0746455140a0880a4d2faf3bb9
Full Text :
https://doi.org/10.9734/bjpr/2014/6055