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A Phase 2a, Double-Blind, Placebo-controlled Randomized Trial of Inhaled TLR9 Agonist AZD1419 in Asthma

A Phase 2a, Double-Blind, Placebo-controlled Randomized Trial of Inhaled TLR9 Agonist AZD1419 in Asthma

Authors :
Vibeke Backer
Mahdi Hashemi
Sofia Necander
Malin Aurell
Piotr Kuna
Ziad Taib
David J. Keeling
Robert L. Coffman
Robert Palmér
Fanyi Jiang
Sara Asimus
Stephen Delaney
Ioannis Psallidas
Katerina Pardali
Katarina Korsback
Joachim Almquist
Per Gustafson
Tariq Sethi
Sam Jackson
Source :
American Journal of Respiratory and Critical Care Medicine. 203:296-306
Publication Year :
2021
Publisher :
American Thoracic Society, 2021.

Abstract

Rationale: To examine the potential of TLR9 (Toll-like receptor 9) activation to modulate the type 2 immune response in asthma.Objectives: To evaluate efficacy and safety of AZD1419, an inhaled TLR...

Details

ISSN :
15354970 and 1073449X
Volume :
203
Database :
OpenAIRE
Journal :
American Journal of Respiratory and Critical Care Medicine
Accession number :
edsair.doi...........84412c619305c6b024e21c1e75b3f234
Full Text :
https://doi.org/10.1164/rccm.202001-0133oc