ChemInform Abstract: Synthesis and Cardiotonic Activity of Aryl- or Pyridyl-Substituted Fused Imidazoles

The syntheses of 4 different fused imidazoles bearing a 2,5-dimethoxyphenyl group or a pyridyl group are reported. All the heterocycles, except 2a , display positive inotropic activity. Some are approximately equipotent with sulmazole, and the imidazo[2,1- b ]benzothiazole that bears a 4-pyridyl group is the most active of whole series.