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ChemInform Abstract: Anti-PKC Activity of Some 3-(Dialkylamino)-1H-naphtho[2,1-b]pyran-1-ones
- Source :
- ChemInform. 29
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- Some 3-(dialkylamino)-1H-naphtho [2,1-b] pyran-1-ones were tested to evaluate their ability to inhibit Protein Kinase C (PKC) activation. The model consisted in the detection of the superoxide anion in activated neutrophils. Naphthopyrans carrying 3-(diethylamino), 3-(1-piperidinyl) and 3-[bis(2-methoxyethyl)amino] groups emerged as the most active ones. Introduction of alkoxy groups in position 8 and 9 and of bromo substituent in position 8 on the naphthalene moiety was associated with an increase in anti-PKC activity. No activity was found when an electron withdrawing group was placed in position 2 of the 3-(dialkylamino)-1H-naphtho [2,1-b] pyran-1-ones.
Details
- ISSN :
- 15222667 and 09317597
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi...........853b3ef94ae50d04034927d32e2c1c9a