Lymphocyte Subpopulation and Activated Eosinophils in Nasal Polyps and Effects of Roxithromycin Therapy

We studied the distribution of T-lmphocyte subpopulations and activated EG2 positive cells in nasal polyps. CD4 positive cells and CD8 positive cells were seen in the epithelium and lamina propria. The CD4/CD8 ratio in nasal polyps was 2.13 on the average. EG2 positive cells were present in nasal polyps, and in the superficial lamina propria extracellular ECP release was seen.Treatment with Roxithromycin lowered the CD4/CD8 ratio in nasal polyps from 2.13 to 0.91, but the distributions of EG2 positive cells did not change.