A dual-response drug delivery system with X-ray and ROS to boost the anti-tumor efficiency of TPZ via enhancement of tumor hypoxia levels

Authors :: Panli Han
Lianxue Zhang
Yaqi Fu
Youyu Fu
Jianxiang Huang
Jinlin He
Peihong Ni
Taimoor Khan
Yang Jiao
Zaixing Yang
Ruhong Zhou
Source :: Nanoscale. 15:237-247
Publication Year :: 2023
Publisher :: Royal Society of Chemistry (RSC), 2023.
Abstract: The selective anti-tumor activity and less toxic nature of hypoxia-activated prodrugs including tirapazamine (TPZ) are harbored by hypoxia levels in tumors, the inadequacy of which leads to failure in clinical trials.

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