Pharmacokinetics of MEDI4736, a fully human anti-PDL1 monoclonal antibody, in patients with advanced solid tumors

Authors :: Meina Liang
Lorin Roskos
Andy Blake-Haskins
Hong Lu
Rajesh Narwal
Aiman Shalabi
Jim Vasselli
David Fairman
Paul B. Robbins
Amy Schneider
Carlos Chavez
Ramy Ibrahim
Min Pak
Source :: Journal of Clinical Oncology. 32:2602-2602
Publication Year :: 2014
Publisher :: American Society of Clinical Oncology (ASCO), 2014.
Abstract: 2602 Background: MEDI4736 is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody directed against human programmed death ligand 1 (PD-L1). MEDI4736 blocks inhibitory interaction of PD-L1 wi...

Subjects :: Cancer Research
Oncology
Pharmacokinetics
business.industry
medicine.drug_class
Medicine
In patient
Pharmacology
business
Ligand (biochemistry)
Monoclonal antibody
Programmed death
Human immunoglobulin

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