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LY6S, a New IFN-Inducible Human Member of the Ly6a Subfamily Expressed by Spleen Cells and Associated with Inflammation and Viral Resistance

Authors :
Moriya Shmerling
Michael Chalik
Nechama I. Smorodinsky
Alan Meeker
Sujayita Roy
Orit Sagi-Assif
Tsipi Meshel
Artem Danilevsky
Noam Shomron
Shmuel Levinger
Bar Nishry
David Baruchi
Avital Shargorodsky
Ravit Ziv
Avital Sarusi-Portuguez
Maoz Lahav
Marcelo Ehrlich
Bryony Braschi
Elspeth Bruford
Isaac P. Witz
Daniel H. Wreschner
Source :
ImmunoHorizons. 6:253-272
Publication Year :
2022
Publisher :
The American Association of Immunologists, 2022.

Abstract

Syntenic genomic loci on human chromosome 8 and mouse chromosome 15 (mChr15) code for LY6/Ly6 (lymphocyte Ag 6) family proteins. The 23 murine Ly6 family genes include eight genes that are flanked by the murine Ly6e and Ly6l genes and form an Ly6 subgroup referred to in this article as the Ly6a subfamily gene cluster. Ly6a, also known as Stem Cell Ag-1 and T cell–activating protein, is a member of the Ly6a subfamily gene cluster. No LY6 genes have been annotated within the syntenic LY6E to LY6L human locus. We report in this article on LY6S, a solitary human LY6 gene that is syntenic with the murine Ly6a subfamily gene cluster, and with which it shares a common ancestry. LY6S codes for the IFN-inducible GPI-linked LY6S-iso1 protein that contains only 9 of the 10 consensus LY6 cysteine residues and is most highly expressed in a nonclassical spleen cell population. Its expression leads to distinct shifts in patterns of gene expression, particularly of genes coding for inflammatory and immune response proteins, and LY6S-iso1–expressing cells show increased resistance to viral infection. Our findings reveal the presence of a previously unannotated human IFN-stimulated gene, LY6S, which has a 1:8 ortholog relationship with the genes of the Ly6a subfamily gene cluster, is most highly expressed in spleen cells of a nonclassical cell lineage, and whose expression induces viral resistance and is associated with an inflammatory phenotype and with the activation of genes that regulate immune responses.

Details

ISSN :
25737732
Volume :
6
Database :
OpenAIRE
Journal :
ImmunoHorizons
Accession number :
edsair.doi...........87646f4a2a00f85fec104172b08a2900
Full Text :
https://doi.org/10.4049/immunohorizons.2200018