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Drug Discovery and Development for Kinetoplastid Diseases
- Source :
- Burger's Medicinal Chemistry and Drug Discovery
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- We review the disease, biology and biochemistry of kinetoplastids, as well as the new drugs and drug candidates that have entered the clinic in the last decade. We also describe examples of the pre-clinical exploration of small molecules against various protein targets, (e.g., cysteine proteases, the proteasome and tubulin), as well as cutting-edge molecular and computational strategies, and technologies being brought to bear to discover and develop new anti-trypanosomal drugs. For comprehensive descriptions of the disease, biology and drug therapies prior to 2011, the reader is encouraged to review the chapter by P. M. Woster that appeared in 2010 in the seventh edition of Burger’s Medicinal Chemistry, Drug Discovery, and Development, with the title Antiprotozoal/Antiparasitic Agents.
- Subjects :
- Drug
0303 health sciences
Drug discovery
business.industry
media_common.quotation_subject
Disease
Computational biology
01 natural sciences
Antiparasitic agent
0104 chemical sciences
010404 medicinal & biomolecular chemistry
03 medical and health sciences
Infectious disease (medical specialty)
Medicine
business
030304 developmental biology
media_common
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Burger's Medicinal Chemistry and Drug Discovery
- Accession number :
- edsair.doi...........87869294de138eba8ccf601921072f10
- Full Text :
- https://doi.org/10.1002/0471266949.bmc235.pub2