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ASSESSING THE ACTIVITY OF MYOPIC CHOROIDAL NEOVASCULARIZATION
- Source :
- Retina. 40:1757-1764
- Publication Year :
- 2019
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2019.
-
Abstract
- Purpose This study aims to suggest a novel strategy for assessing the activity of myopic choroidal neovascularization (mCNV) based on optical coherence tomography angiography (OCTA) and to compare it with traditional fundus fluorescein angiography as the gold standard. Methods Macular OCTA images were obtained using RTVue XR Avanti with AngioVue. Morphologic features of mCNV lesions were analyzed. Characteristics of OCTA in 41 eyes with active mCNV and 41 eyes with inactive mCNV were analyzed. Optical coherence tomography angiography parameters associated with mCNV activity and the clinical significance of their sensitivity and specificity were analyzed using fundus fluorescein angiography as the reference. Results Of the total 108 patients, 82 had OCTA images with good quality which were included in this study. Several anatomical features of the CNV lesions, including overall appearance, branching with tiny vessels, presence of anastomoses/loops, and choroidal dark halo, were considered the possible parameters associated with mCNV activity. The intra- and interobserver agreements were substantial. To evaluate the CNV activity, sensitivity of overall appearance, tiny vascular branching, and presence of anastomoses or loops were 65.9%, 82.9%, and 73.2%, respectively, whereas the specificity was 87.8%, 90.2%, and 92.7%, respectively. However, the choroidal dark halo showed low specificity (46.3%) and failed in terms of evaluating the activity of mCNV. A novel comprehensive procedure integrating branching as a major parameter and overall appearance and presence of anastomoses/loops as minor parameters was developed to evaluate mCNV activity with sensitivity of 95.1% and specificity of 85.4%. Conclusion In mCNV, the acquisition rate of clear OCTA images was 75.9%. A novel comprehensive diagnostic procedure combining mCNV appearance, vascular branching, and anastomoses/loops by OCTA may be a valuable strategy to evaluate neovascular activity in mCNV.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
genetic structures
medicine.diagnostic_test
business.industry
General Medicine
Optical coherence tomography angiography
Anastomosis
eye diseases
Acquisition rate
03 medical and health sciences
Ophthalmology
030104 developmental biology
0302 clinical medicine
Myopic choroidal neovascularization
Angiography
030221 ophthalmology & optometry
Medicine
sense organs
business
Fundus fluorescein angiography
Subjects
Details
- ISSN :
- 0275004X
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Retina
- Accession number :
- edsair.doi...........883c27b83cb362abc1a6d02bae7ea030
- Full Text :
- https://doi.org/10.1097/iae.0000000000002650