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Association between obesity and hospitalization in mild COVID-19 young adult outpatients in Brazil: a prospective cohort study

Authors :
Amanda Paz Santos
Fernanda Hammes Varela
Marcelo Comerlato Scotta
Caroline Nespolo de David
Thaís Raupp Azevedo
Regis Goulart Rosa
Luciane Beatriz Kern
Gabriela Oliveira Zavaglia
Ivaine Tais Sauthier Sartor
Renato T. Stein
Ingrid Rodrigues Fernandes
Victor Bertollo Gomes Porto
Márcia Polese-Bonatto
Gabriela H. Telo
Walquiria Aparecida Ferreira de Almeida
Publication Year :
2021
Publisher :
Cold Spring Harbor Laboratory, 2021.

Abstract

Background/ObjectivesThe aim of this study was to evaluate the association between obesity and hospitalization in mild COVID-19 adult outpatients in Brazil.Subjects/MethodsAdults with signs and symptoms suggestive of acute SARS-CoV-2 infection who sought two hospitals (one public and one private) emergency department (ED) were prospectively enrolled. Patients with confirmed COVID-19 at inclusion were followed by phone calls at day (D) D7, D14 and D28. Multivariable logistic regression models were employed to explore the association between obesity and other potential predictors for hospitalization.ResultsA total of 1,050 participants were screened, 310 were diagnosed with COVID-19 by RT-PCR. Median age was 37.4 (IQR 29.8-45.0) years, and 186 (60.0%) were female. Duration of symptoms was 3.0 (IQR 2.0-5.0) days, and 10.0 (IQR 8.0-12.0) was the median number of symptoms at inclusion. A total of 98 (31.6%) were obese, and 243 (78.4%) had no previous medical conditions. Twenty three participants (23/310, 7.4%) required hospitalization during the period. After adjusting, obesity (BMI≥30.0 kg/m2) (OR=2.69, 95%CI 1.63-4.83, PConclusionsObesity, followed by aging, was the main factor associated with hospital admission for COVID-19 in a young population in a low-middle income country. Our findings highlighted the need for actions to promote additional protection for obese population, such as vaccination, and to encourage lifestyle changes.

Details

Database :
OpenAIRE
Accession number :
edsair.doi...........888be623a291bdb0f2d3a84d43e46141
Full Text :
https://doi.org/10.1101/2021.08.04.21261538