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Can Individualized-Targeted Computerized Cognitive Training Benefit Adults with HIV-Associated Neurocognitive Disorder? The Training on Purpose Study (TOPS)
- Source :
- AIDS and Behavior. 25:3898-3908
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Half of people with HIV (PWH) have HIV-associated neurocognitive disorder (HAND). This study examined whether cognition can be improved using a framework targeting impaired individual cognitive domains in PWH with HAND. In this two-group pre-post experimental design study, 88 adults with HAND were randomized to either: (1) a no-contact control group (n = 40) or (2) the Individualized-Targeted Cognitive Training group (n = 48). Baseline cognitive performance was assessed on eight cognitive domains. A theoretical framework was used to determine the two cognitive domains selected for training. With priority on speed of processing (SOP) and attention impairments, participants received SOP and/or attention training if such impairments were detected; if not, participants were assigned to cognitive training in one/two of the least impaired cognitive domains contributing to their HAND diagnosis. Global cognitive score was slightly improved following training (p = 0.256; d = − 0.21), but it was not significant. Significant improvements were observed on SOP following training in that domain (SOP; d = − 0.88; p = 0.011). SOP training also improved functioning in other cognitive domains. This individualized cognitive intervention did not change HAND status, but it did result in improved SOP, in turn yielding improvement in other cognitive domains.
- Subjects :
- Cognitive Intervention
medicine.medical_specialty
animal structures
030505 public health
Social Psychology
Public Health, Environmental and Occupational Health
Cognition
HIV-associated neurocognitive disorder
medicine.disease
Cognitive training
03 medical and health sciences
Health psychology
0302 clinical medicine
Infectious Diseases
Physical medicine and rehabilitation
medicine
030212 general & internal medicine
Effects of sleep deprivation on cognitive performance
0305 other medical science
Psychology
Neurocognitive
Cognitive reserve
Subjects
Details
- ISSN :
- 15733254 and 10907165
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- AIDS and Behavior
- Accession number :
- edsair.doi...........88c62e2c908cee34c52c229845f9ff46