In Vivo Experiments with Intraluminal Ultrasound Applicator Compatible with 'Real-Time' MR Temperature Mapping, designed for Oesophagus Tumour Ablation

High intensity ultrasound has shown considerable ability to produce precise and deep thermal coagulation necrosis. Focused, cylindrical, spherical or plane transducers have been used to induce high temperature elevation in tissues, in order to coagulate proteins and kill cells. Magnetic Resonance Imaging (MRI) has been used, with focused transducers and cylindrical interstitial applicators, to monitor temperature distribution and provide temperature feedback control during heating procedures. The active part of intraluminal applicators is positioned very close to the target region. It is therefore essential to provide accurate monitoring of heat deposition in the tissue layer near the transducer, in order to control the extension of coagulation necrosis. The purpose of this study was to develop a 10‐mm diameter intraluminal ultrasound applicator, designed to treat oesophageal cancers and compatible with “real‐time” MR temperature mapping. The ultrasound applicator was tested in vivo under real time, PRF b...