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Synthesis ofthreo-3-Methylcysteine from Threonine
- Source :
- Bulletin of the Chemical Society of Japan. 55:3878-3881
- Publication Year :
- 1982
- Publisher :
- The Chemical Society of Japan, 1982.
-
Abstract
- threo-3-Methyl-D-cysteine as a moiety of β-methyllanthionine in the peptide antibiotic nisin was synthesized stereospecifically. The reaction of (2R,3R)-3-methyl-2-aziridinecarboxylic acid derivative prepared from D-threonine with thiobenzoic acid gave the β-mercapto α-amino acid derivative of the same configuration as the starting material. A stereochemistry of the product was retained as a result of double inversion mechanism through the reactions. Thus, we could prepare threo-3-methyl-D-cysteine, i.e., (2S,3S)-2-amino-3-mercaptobutanoic acid which is required for the synthetic study of nisin.
Details
- ISSN :
- 13480634 and 00092673
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Bulletin of the Chemical Society of Japan
- Accession number :
- edsair.doi...........8a41813ca6209694f1c8b12067f4c400