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The Efficacy of Subcutaneous Versus Oral Methotrexate in Patients with Juvenile Idiopathic Arthritis
- Source :
- Bangladesh Journal of Child Health. 33:22-26
- Publication Year :
- 1970
- Publisher :
- Bangladesh Journals Online (JOL), 1970.
-
Abstract
- Objective: To investigate the efficacy of subcutaneous versus oral methotrexate in patients with Juvenile Idiopathic Arthritis (JIA) according to ACR 30 improvement criteria. Design: Prospective control trial (Parallel design) study. Setting: This study was carried out in the department of Paediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, during the period from September 2006 to April 2008. Patients: A total of 40 patients participated in the study. They were divided in 2 equal groups (Group A and Group B) alternatively matching with age, sex, and subtypes of the disease. Methotrexate was given orally in group A patients and subcutaneously in group B patients. Results: Amomg the core set variables active arthritis had the highest percentage of improvement in both the groups and laboratory criteria (ESR) showed lowest improvement. According to ACR-30 criteria, improvement rate was higher in the subcutaneous group than oral group (85% versus 65%). Side effects of MTX were also less in subcutaneous group than oral group. Conclusion: From this study it may be concluded that the efficacy of subcutaneous MTX is more than oral MTX in JIA patients. Key words: Subcutaneous; oral; methotrexate; juvenile idiopathic arthritis. DOI: 10.3329/bjch.v33i1.5671 Bangladesh Journal of Child Health 2009; Vol.33(1): 22-26
Details
- ISSN :
- 24088315 and 02573490
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Bangladesh Journal of Child Health
- Accession number :
- edsair.doi...........8a87b912dd8bf9ef0d48b74fceb4d99d