Abstract 10207: Association Between Age and the Von Willebrand Factor-ADAMTS13 Axis in Patients with ST-Elevation Myocardial Infarction

Introduction: The incidence of arterial thrombosis increases with age, but its underlying mechanisms are unclear. Myocardial infarction is associated with increased von Willebrand factor (VWF) and decreased a disintegrin-like and metalloproteinase with thrombospondin type-1 motif 13 (ADAMTS13) levels. We aimed to examine the relationship between the VWF-ADAMTS13 axis and age in ST-elevation myocardial infarction (STEMI). Methods: Patients who underwent endovascular arterial recanalization for STEMI or acute ischemic stroke (AIS) and had aspirated thrombi at our institute between June 2019 and August 2020 were enrolled. Seventy-one patients were divided into two age groups— Results: Among all patients (STEMI and AIS), ADAMTS13 levels were significantly lower in the ≥65 years group than in the Conclusions: Our study demonstrated low ADAMTS13 levels in elderly patients with STEMI, but not in those with AIS. The VWF-ADAMTS13 axis may be more involved in the pathogenesis of STEMI than in that of AIS among elderly patients.