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COGNITIVE IMPAIRMENT OCCURS BEFORE LOSS OF FUNCTION IN ALS
- Source :
- Journal of Neurology, Neurosurgery & Psychiatry. 87:e1.239-e1
- Publication Year :
- 2016
- Publisher :
- BMJ, 2016.
-
Abstract
- Objectives Using a historical amyotrophic lateral sclerosis (ALS) dataset comprising detailed cognitive and clinical assessments, we used a novel event-based model to analyse the likely ordering of these biomarkers in the progression of ALS. Methods The dataset was derived from a cross-sectional sample of 28 ALS patients who were not classified as having ALS-FTD and 26 matched controls (see1 regarding cognitive and clinical assessments). The event-based model was adapted for ALS from previous work in Alzheimer9s disease.23 Unlike traditional models of disease progression, event-based models do not rely on a priori staging of patients but extract the event ordering directly from the data, thus minimising subjective bias. Results The most likely order of progression showed that changes in executive function occur at an early stage of disease evolution. Language impairment tended to occur after executive dysfunction. Changes in functional ability assessed by rate of change of ALSFRS-R occurred after the changes in executive function. Conclusions These findings suggest that executive dysfunction occurs early in the evolution of ALS.
- Subjects :
- medicine.medical_specialty
Disease progression
Cognition
medicine.disease
Psychiatry and Mental health
Physical medicine and rehabilitation
medicine
Surgery
Neurology (clinical)
Functional ability
Amyotrophic lateral sclerosis
Cognitive impairment
Psychology
Neuroscience
Loss function
Executive dysfunction
Event (probability theory)
Subjects
Details
- ISSN :
- 1468330X and 00223050
- Volume :
- 87
- Database :
- OpenAIRE
- Journal :
- Journal of Neurology, Neurosurgery & Psychiatry
- Accession number :
- edsair.doi...........8b756db7aed811a4f063a4cbcff625c1