Energy-conversion nanomedicine and biomaterials

Severe side effects on the surrounding normal tissues and low therapeutic efficiency hinder the further biomedical applications of conventional cancer therapies (chemotherapy, radiotherapy, surgery, etc.). With the rapid development of nanotechnology and nanomedicine, energy-conversion biomaterial-mediated therapies have received extensive attention due to their non-invasive feature, high tissue-penetration depth and precise regulation of therapeutic doses. In this review, we summarize our recent research progress on the design of energy-conversion biomaterials (photo-to-thermal energy conversion, photo-to-chemical energy conversion conversion, ultrasound-to-chemical energy, ultrasound-to-thermal energy conversion, magnetic field-to-thermal energy conversion, and chemical energy-to-chemical energy conversion) and their application in cancer treatment, and discuss the prospects and challenges of energy-conversion nanomedicine in the future clinical translation.