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Diagnostic utility of Cytokeratin 13 and Cytokeratin 17 in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma
- Source :
- Asian Pacific Journal of Cancer Biology. 5:153-158
- Publication Year :
- 2020
- Publisher :
- EpiSmart Science Vector Ltd, 2020.
-
Abstract
- Objective: To determine the immunohistochemical expression of CK 13 and CK 17 in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma. Methods: A total of 170 cases were retrieved from record files of Histopathology Department, to conduct a cross sectional study at Armed Forces Institute of Pathology, Rawalpindi, over a period of one year from June 2018 to June 2019 along with their formalin-fixed, paraffin embedded blocks comprising 85 cases of each oral squamous cell carcinoma and oral epithelial dysplasia. Blocks were trimmed and cut into very thin sections of 5 microns using microtome and mounted on slides. Tissue mounted slides were stained with routine haematoxylin and eosin followed by immunohistochemical staining of cytokeratin 13 and cytokeratin 17. New histological diagnosis of each case was made. Mean and standard deviation were calculated for quantitative variables. Frequency and percentages were calculated for qualitative variables. Chi-square test was employed to assess the significance of difference. The P-value
- Subjects :
- Pathology
medicine.medical_specialty
Epithelial dysplasia
Invasive carcinoma
business.industry
Building and Construction
Haematoxylin
medicine.disease
Cytokeratin
chemistry.chemical_compound
chemistry
Dysplasia
medicine
Over expression
Immunohistochemistry
Basal cell
Electrical and Electronic Engineering
business
Subjects
Details
- ISSN :
- 25384635
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Asian Pacific Journal of Cancer Biology
- Accession number :
- edsair.doi...........8c3a307f9f6acd409e4c348b96fb1a5b
- Full Text :
- https://doi.org/10.31557/apjcb.2020.5.4.153-158