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Diagnostic utility of Cytokeratin 13 and Cytokeratin 17 in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma

Authors :
Muhammad Asif
Muhammad Ishaque
Maryam Nazir Kiani
Nighat Ara
Amna Riaz Khan
Fakeha Meraj Ansari
Source :
Asian Pacific Journal of Cancer Biology. 5:153-158
Publication Year :
2020
Publisher :
EpiSmart Science Vector Ltd, 2020.

Abstract

Objective: To determine the immunohistochemical expression of CK 13 and CK 17 in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma. Methods: A total of 170 cases were retrieved from record files of Histopathology Department, to conduct a cross sectional study at Armed Forces Institute of Pathology, Rawalpindi, over a period of one year from June 2018 to June 2019 along with their formalin-fixed, paraffin embedded blocks comprising 85 cases of each oral squamous cell carcinoma and oral epithelial dysplasia. Blocks were trimmed and cut into very thin sections of 5 microns using microtome and mounted on slides. Tissue mounted slides were stained with routine haematoxylin and eosin followed by immunohistochemical staining of cytokeratin 13 and cytokeratin 17. New histological diagnosis of each case was made. Mean and standard deviation were calculated for quantitative variables. Frequency and percentages were calculated for qualitative variables. Chi-square test was employed to assess the significance of difference. The P-value

Details

ISSN :
25384635
Volume :
5
Database :
OpenAIRE
Journal :
Asian Pacific Journal of Cancer Biology
Accession number :
edsair.doi...........8c3a307f9f6acd409e4c348b96fb1a5b
Full Text :
https://doi.org/10.31557/apjcb.2020.5.4.153-158